- Lady Snowblood
- Oyuki is a seductive and beautiful woman, with formidable skills in using a blade hidden in her umbrella. She has been entrusted with the task of vengeance by her mother to kill the three people who murdered her brother and father.
- Miyanara San
- A writer who pens the Oyuki's story in an effort to draw the final two tormentors out in the open. Although antagonistic at first, he comes to treat Oyuki as his daughter even risking his life to assist in her quest.
- Matsuemon San
- The leader of a band of beggars who assists Oyuki in discovering the location of her kill list in return for Oyuki stealing a hojicho for him.